Real-time organic synthesis reaction monitoring is an important for maximizing efficiency and reducing waste by measuring the the % reaction completion or the production of impurities or byproducts.
However, spectroscopic methods (ie, FTIR, NIR, UV/VIS) that non-invasively provide continuous data about the reaction can only provide limited information about actual molecular structure, and more rigorous techniques such as Mass Spectrometry or NMR have traditionally been too slow and expensive to be efficacious.
Most organic and medicinal chemists thus use indirect methods to monitor the reaction in real-time and then use NMR as a final step to confirm the structure of their molecule of interest.
While traditional, high-field NMR systems are not designed to analyze samples in continuous flow due to their needs for cyrogenic conditions and their need to spin the sample to achieve sensitivity, we at Magritek have developed a solid-state NMR system that can provide structural and quantitative measurement of the molecules within the reaction chamber.
The Magritek SpinSolve Benchtop NMR system's design is optimized to achieve exceptionally high-resolution NMR-quality spectra very quickly, without the need for cyrogenics or sample spinning. Further, normal (protonated) solvents can be used, without the need to deuterate the samples.
Further, the SpinSolve system is designed with a completely open bore from top to bottom, allowing for a flow-cell to mount within the magnet, pumping a continuous flow of the sample from your reaction chamber into the magnet for spectral analysis.
We believe this system can provide valuable information and help increase efficiency of organic syntheses. But we want to hear your feedback. We have prepared a short, 6-question survey for you to provide us with your thoughts. Please lick the link to the right and provide us with your reactions to the information we have presented.Answer the short survey